Four people – would-be singer Harrison, waitress Julia, working mom Penny and street thug Milo – die in a bus accident. As spirits, they find themselves bound to the newborn Thomas Reilly and become his imaginary friends for a portion of his childhood. When Thomas's parents consider putting him in a mental hospital, the four ghosts decide to make themselves invisible to Thomas to help him grow up.
Years later, Harrison, Julia, Penny and Milo learn that they were supposed to use Thomas as a host to fulfill their unfinished business on Earth, so they make themselves visible to Thomas, now an adult, once again and Thomas now has to help his old friends before they become stuck on Earth forever.
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