Hibiki and Kanade are two friends who grew up together in Kanon Town. Very different in their personalities, they share one thing in common: A connection to music. No matter how different they are or how much their differences cause them to quarrel, they both continue to share loving hearts. One day they meet Hummy, who is sent to the Human World from Major land to search for the new Pretty Cures to collect the scattered notes of the Melody of Happiness. They have to instantly transform into Pretty Cures to resist the threats and evil music from Mephisto. Can they stop the Melody of Pain from disrupting their peaceful town, and can their warped friendship measure up to the bonds of Pretty Cure?
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