Sara Pezzini, a tough-as-nails NYPD homicide detective comes into possession of the Witchblade, a supernatural, sentient artifact with immense destructive and protective powers. The weapon has bonded with various women throughout history, the most recent being Danielle Baptiste. Others who have come into contact with the Witchblade include Cleopatra and Joan of Arc. Sara struggles to hone the awesome powers of the Witchblade and fend off those with a nefarious interest in it, especially entrepreneur Kenneth Irons. She also struggles to maintain a personal life.
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