The game's plot revolves around an organization known as M.A.Y.H.E.M. (Multinational Agency Hunting Evil Masterminds), founded by Persephone Brimstone (a character first seen in Gat out of Hell) and funded by the Ultor Corporation (one of the main antagonists of Saints Row 2 and the Red Faction series, later merging with the Saints in Saints Row: The Third). Bearing the Saints' purple fleur-de-lis logo, M.A.Y.H.E.M's goal is to stop supervillain organization L.E.G.I.O.N. (the League of Evil Gentleman Intent on Obliterating Nations) from destroying the world's nations. The game is set in a near-future version of Seoul, South Korea.
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