Based on the controversial sixth installment in Capcom's survival horror video game series. Some creative liberties will be taken so a live-action version of this hated game can be translated to an entertaining movie experience.
The Story: Even after the defeat of Albert Wesker in 2009, his influence in biological warfare is still felt, as B.O.W.s are still being manufactured across the globe. To make matters worse, a terrorist group calling themselves Umbrella Next (putting “Neo” in front of everything doesn't make it better), look to oversee the rebirth of Umbrella. With the use of a newly perfect strain known as the C-Virus, they plan to control the minds of every human to do their bidding. This forces heroes of Biohazard past to unite with old friends and new allies to investigate this new threat.
One of them is Leon S. Kennedy, once a rookie cop in Raccoon City now a government agent. He is asked by Adam Benford - friend of the family soon to become President of the United States - to guard him as he reveals his part in the Raccoon City Incident during his speech at Tall Oaks University. However, an outbreak is unleashed, turning everyone into zombies, including the President himself. Leon bids farewell as he takes Benford down. Also present with him is Helena Harper, a secret service agent who reveals her part in this mysterious outbreak. Turns out the mastermind behind it all was Derek C. Simmons, a National Security Advisor who is the head of The Family, a group of people who had long sought to create order in the world even before the Revolutionary War, choosing to build up the United States' power and influence over the centuries. Were the US/Umbrella link to be revealed, it was feared that balance would collapse entirely. So Derek eventually forced Helena to assist him or have the blood of her sister Deborah on her hands. Thus Leon and Helena escaped the Tall Oaks outbreak by the skin of their teeth and hope to get revenge on Derek.
Meanwhile, B.S.A.A. captain Chris Redfield, now a violent drunkard after a devastating event traumatized him, has been located by Piers Nivens, a young member of the agency, to help Chris confront his past. It turns out that the B.S.A.A., who expanded their resources and also became a military unit, investigated the use of bioweaponry in Edonia at the end of 2012. Eventually, the unit was caught off guard by Ada Wong, and set off a weapon that would turn them all into a new breed of B.O.W. known as Napads. One of them knocked Chris unconscious, leaving him with post-traumatic amnesia. At present time, Chris agrees to Piers' offer, hoping to get himself together and uncover what happened.
At the same time, we meet Jake Muller, a wisecracking and brash mercenary of the South-Slavic Edonian Liberation Army. After fighting off J'avo, he has a chance meeting with Sherry Birkin, one of the survivors of the Raccoon City incident, now working for the government to eradicate bioterrorists. Sherry notices that the injections that Jake was taking, which were laced with the C-Virus, had no affect on him, leading her to believe that he has antibodies that could help a lot of people. Despite his crude attitude and strict bargaining tactics, Jake willingly helped out. However, they were captured by Ada Wong, who was also in Edonia at the time Chris Redfield lost his unit at her hand. Ada identifies Jake as being the son of Albert Wesker, and that he possesses “something” that will help her accomplish her goals. This leads to an arduous six months of experiments, which the duo managed to escape from. The two eventually run into Sherry's old friend, Leon S. Kennedy, along with Helena Harper, where they overhear that Sherry's boss Derek was behind the outbreak in Tall Oaks.
All their paths converge in a race against time to stop Umbrella Next from unleashing hell on Earth. But can they conquer the demons of their past, or will they be forced the walk the Earth amongst the undead? And how does Ada Wong fit in all this?
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