Brotherss Bo and Luke Duke are on the run from Sheriff Roscoe again after Boss Hogg frames them for distributing un-taxed tobacco. They evade him but on their way back to their uncle's farm, they discover an empty house filled with immigrants who have fled their country. They help them to get to safety, but they encounter the ruthless businessman who brought them to America - Tyrell Oliver. When Bo and Luke return home, they tell Jesse about what happened, but are distracted by the arrival of their Welsh cousin on Daisy Duke's side of the family - Sally Laughton - from across the pond. Daisy learns from a FBI agent, disguised as a car mechanic, that Oliver is under investigation for human trafficking. She tells Sheriff Roscoe this, but he says that Hogg is about to secure a business deal with the evil entrepreneur. The cop's conscience gets the better of him and he reluctantly teams up with the Duke family to bring Tyrell Oliver down, even if it means losing favour with Hogg.
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