"It was the time of the preacher..."
Jesse Custer is a small town minister slowly losing his faith... until he merges with a half angelic, half demonic being called Genesis. Together with Tulip, Jesse's trigger happy ex-lover, and Cassidy, a hard drinking Irish vampire, Jesse sets out on a bizarre road trip from the heart of Texas to find God who has abandoned his throne in heaven. Hunting them are The Saint of Killers, who is out to stop Genesis and The Grail, a society constructed for the sole purpose of preserving the divine bloodline.
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